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BEGIN:VEVENT
DTSTAMP:20260627T164956Z
DTSTART;VALUE=DATE-TIME:20161129T130000
DTEND;VALUE=DATE-TIME:20161129T140000
SUMMARY:Seminar: The Clock Over The Clock
TZID:Europe/London
UID:20161129-094d4345586d685a01588b6d05d969c8@warwick.ac.uk
CREATED:20161122T094527Z
DESCRIPTION:Speaker: Dr Antonia Tomas Loba Abstract: Why almost everythin
 g in Nature is rhythmic? And beyond\, why being rhythmic is most of the 
 time healthy and being arrhythmic seems to be unhealthier? Evolution has
  found a way to synchronize what is happening outside with our internal 
 bodies in a complex way called Circadian Rhythms. This process is a 24h 
 oscillations tuned by light\, where the Suprachiasmatic Nucleus (SCN)\, 
 in the hypothalamus\, is able to transduce the light signal\, in a refin
 e cellular program that anticipates and synchronizes our body to externa
 l changes. However not only light is an entrainment that regulates our p
 hysiology\, but also feeding time\, temperature\, exercise\, and other e
 xternal cues\, have the ability to fine tune our body with the environme
 nt. How this is coordinated in the brain to regulate body homeostasis\, 
 is an extremely interesting question that it has not been elucidated. Th
 us it is the first aim of the project. What does happen when our biologi
 cal rhythms are disrupted by being exposed to external cues at the wrong
  time of the day? We are increasing the risk of developing several disea
 ses. Understanding how the circadian rhythm disruption leads to cancer a
 nd mood disorders and the connection between them\, is another big aim I
  will work on. In addition\, it has been shown that p38 Mitogen Activate
 d Kinase (p38 MAPK) proteins are activated by light in different models\
 , but nothing is known about its role beyond the SCN regulating other st
 imuli centres. The concept of p38 MAPK being the engager regulating diff
 erent clocks is not fully defined in the circadian rhythm and MAPK field
 s and it is also one of my aims. Genetically engineered mouse models\, u
 sing advance techniques including CRISPR-Cas9\, and new gene/drug delive
 ry systems (stereotactic protocols) and the state-of-the-art cellular\, 
 biochemical and molecular protocols will be employed to answer the propo
 sed aims proposed.
LOCATION:GLT4\, 91¸£Àû Medical School
CATEGORIES:BiomedicalSciences,DivisionalSeminars,BMS_TEM
LAST-MODIFIED:20161122T100325Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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