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BEGIN:VEVENT
DTSTAMP:20260611T134605Z
DTSTART;VALUE=DATE-TIME:20260429T131500
DTEND;VALUE=DATE-TIME:20260429T141500
SUMMARY:BMS Seminar: The chemo-mechanical regulation of brain development
 \, Professor Kristian Franze\, Department of Physiology\, Development an
 d Neuroscience\, University of Cambridge
TZID:Europe/London
UID:20260429-8ac672c49a2faca3019a356c61132af6@warwick.ac.uk
CREATED:20260428T110049Z
DESCRIPTION:Abstract: During development\, cells are highly dynamic and r
 espond to a plethora of chemical and mechanical signal in their environm
 ent. During brain morphogenesis\, for example\, neurons extend axons ove
 r large distances along well-defined pathways. How these axons are forme
 d is currently poorly understood\, and once initiated\, how axons know w
 here to grow and connect is also still an open question. Axon pathfindin
 g is regulated by both gradients of chemical guidance cues and gradients
  in tissue stiffness. However\, we currently know very little about how 
 these signals interact. Using a combination of ex vivo and in vivo appro
 aches\, we identified the mechanosensitive ion channel Piezo1 as a key i
 ntegrator of chemical and mechanical signals. Downregulation of Piezo1 i
 n the brain parenchyma surrounding healthy growing axons led to aberrant
  neuronal growth patterns with reduced fasciculation and pathfinding err
 ors. We found a decrease in both the chemical guidance cues Semaphorin3A
  and Slit1 and brain stiffness. While the stiffness of cells was unaffec
 ted\, cell-cell adhesion was significantly reduced\, leading to a fluidi
 zation of the tissue. While a decrease in chemical guidance cues did not
  lead to tissue softening\, tissue softening led to a decrease in guidan
 ce cues. Hence\, tissue stiffness not only directly impacts neuronal gro
 wth but also indirectly by regulating the availability of long-range che
 mical guidance cues far away from the actual mechanical signal in the su
 rrounding tissue. Our data thus strongly indicate that chemical and mech
 anical signaling pathways are intimately linked\, and that their interac
 tion is crucial for morphogenetic events. Biography: Kristian Franze qua
 lified as a Veterinarian at the University of Leipzig in Germany\, where
  he also obtained a PhD in Physics in 2007. After a postdoc at the Caven
 dish Laboratory of the University of Cambridge\, UK\, he started his lab
  in 2011 at the Department of Physiology\, Development and Neuroscience 
 in Cambridge. Kristian received several awards for his work\, including 
 an MRC Career Development Award\, an HFSP Young Investigator Award\, an 
 ERC Consolidator Award\, and an ERC Synergy Grant. In 2020\, he obtained
  an Alexander von Humboldt-Professorship to become the Director of the M
 edical Institute of Biophysics at FAU and of the newly founded Max Planc
 k Zentrum für Physik und Medizin in Erlangen\, Germany. The research of 
 his lab focuses on how mechanical signals\, such as cellular forces or t
 issue stiffness\, contribute to regulating the development and regenerat
 ion of the nervous system.
LOCATION:MTC Lecture Theatre \, Gibbet Hill Campus
CATEGORIES:BiomedicalSciences,Directorate Seminars
LAST-MODIFIED:20260428T110049Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
END:VCALENDAR