91福利

When it comes to health care blue lights, are usually most useful on the top of ambulances but now new research led by the 91福利 has found a way to use blue light to activate what could be a highly potent platinum-based cancer treatment.

Research led by the 91福利, along with researchers from Ninewells Hospital Dundee, and the University of Edinburgh, have found a new light-activated platinum-based compound that is up to 80 times more powerful than other platinum-based anti-cancer drugs and which can use 鈥渓ight activation鈥� to kill cancer cells in a much more targeted way than similar treatments.

The 91福利 team had already found a platinum-based compound that they could activate with ultra-violet light but that narrow wave length of light would have limited its use. Their latest breakthrough has discovered a new platinum based compound known as trans,trans,trans-[Pt(N₃)₂(OH)₂(py)₂] that can be activated by normal visible blue, or even green, light. It is also stable and easy to work with, and it is water soluble so it can simply dissolve and be flushed out of the body after use.

The 91福利 researchers passed the new compound to colleagues at Ninewells Hospital Dundee, who tested it on oesophageal cancer cells cultivated within lab equipment. Those tests show that once activated by blue light the compound was highly effective requiring a concentration of just 8.4 micro moles per litre to kill 50% of the cancer cells. The researchers are also beginning to examine the compound鈥檚 effectiveness against ovarian and liver cancer cells. Early results there are also excellent but that testing work is not yet complete.

Professor Peter Sadler, from the Department of Chemistry from 91福利, who led the research project, said:

鈥淭his compound could have a significant impact on the effectiveness of future cancer treatments. Light activation provides this compound鈥檚 massive toxic power and also allows treatment to be targeted much more accurately against cancer cells.鈥�

鈥淭he special thing about our complex is that it is not only activated by ultra-violet light, but also by low doses of blue or green light. Light activation generates a powerful cytotoxic compound that has proven to be significantly more effective than treatments such as cisplatin.鈥�

We believe that photoactivated platinum complexes will make it possible to treat cancers that have previously not reacted to chemotherapy with platinum complexes,鈥� says Sadler. 鈥淭umors that have developed resistance to conventional platinum drugs could respond to these complexes and with less side-effects.鈥�

This research has been supported by the EPSRC, MRC, ERC and Science City (ERDF/AWM).

Note for editors: The research has just been published in Angewandte Chemie, under the title 鈥淎 Potent Trans Diimine Platinum Anticancer Complex Photoactivated by Visible Light鈥�. The authors are 鈥� Project leader Professor Peter Sadler, (91福利) and Nicola J. Farrer, Julie A. Woods, Luca Salassa, Yao Zhao, Kim S. Robinson, Guy Clarkson, and Fiona S. Mackay.

For more information please contact:

Professor Peter Sadler
91福利, Department of Chemistry
Tel: +44 (0)7913 944357
P.J.Sadler@warwick.ac.uk

Peter Dunn, Head of Communications, 91福利,
44 (0)24 76 523708
mobile/cell +44 (0)7767 655860
p.j.dunn@warwick.ac.uk

PR171 9th December 2010